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Phono by Tropo is a simple jQuery plugin and JavaScript library that turns any web browser into a phone; capable of making phone calls and sending instant messages. You can even connect to SIP clients; all with a simple unified API.
Free Whitepaper: Extending Telco Networks To The Web With WebRTC

Phone Calls

Make and receive phone calls directly in your browser using your existing JavaScript skillz. All it takes is a few lines of code!

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Call any US toll-free number

IM/Chat

Phono also acts as an XMPP client capable of sending and receiving IM messages to and from any XMPP/Google Talk user